The Graduate School’s courses have been developed by expert educators and scientists to maximize impact and innovative thinking.
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In a progressive series of four-week modules, students develop research plans to address current hypotheses, questions or problems relevant to human disease. As part of developing these plans, students learn core and current concepts in biochemistry, cell biology, molecular biology, genetics, bioinformatics, and pathobiology. This problem-based learning approach best simulates how professional scientists attack new research problems. Students emerge with a strong foundation in core concepts in the relevant disciplines, an understanding of experimental design principles, and experience in crafting research plans. The fall and winter semesters of SABR each comprise four two-credit modules and a one-credit cumulative final examination.
This course examines the historical context of current molecular and cell biology research. Students study classic papers in biomedical research and discuss how the work represented in those papers changed the models or paradigms that prevailed at the time the research was done. Topics include foundations of modern biology, mechanisms of genetic change, analysis of biological macromolecules, gene splicing and rearrangement, tumor viruses, oncogenes and tumor suppressor genes, and organisms used as important experimental models.
This course reviews the process of scientific discovery at the bench through the steps of translation and implementation to the bedside. This course will begin with the discovery of biomarker characteristics required to meet clinical utility with discussion on the development of drugs for therapeutic targets. Students will review the onerous process of moving a drug target into the clinic and through the organization of clinical trials. Students also will examine elements of regulation, clinical trial biostatistics, correlative science, and entrepreneurship and review use-case examples of the steps from discovery to translation.
This course addresses effective laboratory management practices including protection of human and animal subjects, scientific integrity, conflicts of interest, collaboration, authorship, peer review, data management, mentoring, communication, societal impacts, human resource management, grants and contracts, and fiscal responsibility. The course provides training and direction on how to recognize, address and prevent ethical dilemmas that arise during the course of conducting scientific research.
Students present recently published scientific papers on topics of general interest and importance to the field of biomedical research. Students will develop logical arguments and determine when arguments have a sound foundation; understand the variety of experimental approaches (i.e., methods), compare approaches, and provide rationale for the approaches presented in the publication; and challenge the outcomes and paradigms of published work. Non-presenting students will submit written reflections and evaluations of the papers and talks given by others.
In weekly or biweekly sessions (respectively), Van Andel Research Institute faculty and graduate students present the current state of their research projects. Non-presenting students will submit written reflections and evaluations of these talks in which they define the “gap in knowledge” and experimental approach; critique the organization and logic of the presentation; question the presenter in order to better understand the research outcomes; and organize their own presentations better as a result of critiquing the logic of others’ talks.
This course is based on invited seminars presented by scientists external to Van Andel Research Institute. Students attend at least 10 seminars per semester and submit a written reflection and evaluation following each seminar.
These courses help build students’ skills in communication, laboratory management, business, and organization. Courses complement the Journal Club, Research in Progress, and VARI seminar courses. Recent offerings include technical writing, lab leadership, and scientific conference organization.
These courses provide advanced study on a focused topic in basic or clinical research, and are typically taken in the second, third, and fourth years. Each course engages students in the study and discussion of the current scientific literature and concepts of the topic selected. Topics vary and usually reflect particular interests of the faculty member(s) who lead the course.
Laboratory rotations in the first year provide early research experiences that are important in the development of students. These laboratory rotations assist students in their choice of a thesis adviser, laboratory, and dissertation project. Students will complete at least three rotations. The activities of the rotation should be planned to give the student a rich and deep understanding of the questions being addressed, the approaches and experimental methods employed, the mentoring and leadership style of the laboratory head, and the relationships with other members of the laboratory team. Students should expect to spend as much time in the laboratory as their course work will allow (typically 25–30 hours per week).
Students request VAIGS academic credit for a course or workshop taken at another institution (whether in-person or online), or for learning experiences at Van Andel Institute Graduate School/Van Andel Research Institute that are not part of existing courses. Requests are evaluated on a case by case basis.