Current Students

Thesis: TME impact on epithelial tumorigenesis in NF1-deficient breast cancer.

Thesis: Uncovering the functionality of PD risk-SNPs at the HLA locus in microglia

Thesis project title to be determined

Thesis: Therapeutically targeting SWI/SNF mutant cancers

Thesis: Structural Basis of Regulation Mechanisms of TRPC3

Investigating the mechanisms of LKB1-mediated inflammation in tumor progression

Thesis: Investigating the roles of lysine-methyltransferases in the epigenetic regulation of cardiac and skeletal myogenesis

Thesis: Genetic modifiers of LRRK2-induced cellular toxicity

Thesis: Structural mechanisms of Wnt-mediated Frizzled activation

Thesis: Genetic characterization of dementia in a Turkish cohort

Thesis project title to be determined

Thesis: Function study of MHC I in central neuronal system

Thesis: Contributions of LRRK2 and alpha-synuclein in neuropathologic phenotypes of Parkinson’s disease

Thesis: Building a mitotic clock

Thesis: Polysumoylation’s role in skeletal development and homeostasis

Thesis: A mechanistic approach to optimize mithramycin administration for the treatment of Ewing sarcoma

Thesis: Predicting response to kinase inhibitors in NF1-related malignancies based on tumor genomics

Thesis: Structural, biochemical and pharmacological analysis of TRP channels in chemosensation and signaling

Thesis: Receptor specificity of Wnt signaling

Thesis project title to be determined

Thesis project title to be determined

Thesis project title to be determined

Defining molecular determinants of methyllysine-driven interactions

Thesis: Identification of trabectedin analogs that improve the suppression of EWS-FLI1

Thesis project title to be determined

Thesis project title to be determined

Thesis: Post-GWAS characterization of Parkinson’s disease risk-SNP rs356182

Thesis project title to be determined

Thesis project title to be determined

Thesis project title to be determined

Thesis: Mechanisms of oncohistone-mediated tumorigenesis

Thesis: The role of polycomb target gene DNA methylation in intestinal tumorigenesis

Thesis: Epigenetic regulation through histone ubiquitination

Thesis: Identifying intramolecular and intermolecular interactions regulating LRRK2 activity and neurotoxicity