VAN ANDEL INSTITUTE
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TME impact on epithelial tumorigenesis in NF1-deficient breast cancer.
Thesis project title to be determined
Thesis: Therapeutically targeting SWI/SNF mutant cancers
Thesis project title to be determined.
Thesis: Investigating the roles of lysine-methyltransferases in the epigenetic regulation of cardiac and skeletal myogenesis
Thesis: Genetic modifiers of LRRK2-induced cellular toxicity
Thesis: Structural mechanisms of Wnt-mediated Frizzled activation
Thesis: Integrative approaches to structural biology
Thesis: Function study of MHC I in central neuronal system
Thesis: Building a mitotic clock
Thesis: A mechanistic approach to optimize mithramycin administration for the treatment of Ewing sarcoma
Thesis: Predicting response to kinase inhibitors in NF1-related malignancies based on tumor genomics
Thesis: Structural, biochemical and pharmacological analysis of TRP channels in chemosensation and signaling
Receptor specificity of Wnt signaling
Thesis: Investigating RAS and RTK signaling in MPNST progression and drug resistance
Thesis: Identification of trabectedin analogs that improve the suppression of EWS-FLI1
Thesis: Post-GWAS characterization of Parkinson’s disease risk-SNP rs356182
Thesis: Mechanisms of oncohistone-mediated tumorigenesis
Thesis: The role of polycomb target gene DNA methylation in intestinal tumorigenesis
Thesis: Epigenetic regulation through histone ubiquitination
Thesis: Identifying intramolecular and intermolecular interactions regulating LRRK2 activity and neurotoxicity