Maggie Chassé

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  Maggie Chassé

  Undergraduate University: Colorado State University (B.A. English Literature and M.S. Biochemistry)
• Thesis: Therapeutically targeting SWI/SNF mutant cancers
• Mentor: Patrick Grohar, M.D., Ph.D.
• Experience: Spent five years in Dr. Karolin Luger’s lab studying chromatin and PARP dynamics. Prior to that, Maggie was a REU intern at the University of Alaska Anchorage studying copper export in the liver.
• Hometown: Eagle River, Alaska
• Hobbies: Craft beer, reading and spending time with my husband Andy, our deaf dog Flurry and our cat Fitzgerald.

Read Maggie’s Student Spotlight Q&A here.

PUBLICATIONS

Gedminas JM, Chasse MH, McBrairty M, Beddows I, Kitchen-Goosen SM, Grohar PJ. 2020. Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor.
Oncogenesis 9(4):41.

Harlow ML*, Chassé MH*, Boguslawski EA, Sorensen KM, Gedminas MJ, Goosen JM, Rothbart SB, Taslim C, Lessnick SL, Peck A, Madaj ZB, Bowman MJ, Grohar PJ. 2019. Trabectedin inhibits EWS-FLI1 and evicts SWI/SNF from chromatin in a schedule-dependent manner. Clin Cancer Res. 
*Equal contributions

Harlow ML*, Chassé MH*, Boguslawski EA, Sorensen KM, Gedminas MJ, Goosen JM, Rothbart SB, Taslim C, Lessnick SL, Peck A, Madaj ZB, Bowman MJ, Grohar PJ. 2019. Trabectedin inhibits EWS-FLI1 and evicts SWI/SNF from chromatin in a schedule-dependent manner. Clin Cancer Res. 
*Equal contributions

Chassé MH, Muthurajan UM, Clark NJ, Kramer MA, Chakravarthy S, Irving T, Luger K. 2017. Biochemical and biophysical methods for analysis of Poly(ADP-Ribose) Polymerase 1 and Its interactions with chromatin. Methods Mol Biol.

Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler MR, Machida S, Yan K, Kurumizaka H, Poirier MG, Côté J, Luger K, Kutateladze TG. 2016. Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic Acids Res 44(1):472–484.

Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. 2014. Molecular functions of the TLE tetramerization doman in Wnt target gene repression. EMBO J 33(7):719–731.

Muthurajan UM, Hepler MR, Hieb AR, Clark NJ, Kramer M, Yao T, Luger K. 2014. Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A 111(35):12752–12755.