Wooyoung Choi

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  Wooyoung Choi

  Undergraduate University: Tsinghua University (B.S. in 2009 and M.S. in 2012)
• Thesis: Structural Basis of Regulation Mechanisms of TRPC3
• Mentor: Wei Lü, Ph.D. 
• Experience: Resolved the structure of Beclin 1, which is an essential autophagic protein. Proposed a new role of glutamine in acid resistance in cancer cells. Determined the binding mechanism of CED4 and CED3, two key proteins in programmed cell death while at Tsinghua University. 
• Hometown: Jeonju, South Korea

Read Wooyoung’s Student Spotlight Q&A here.

PUBLICATIONS

Choi W#, Clemente N#, Sun W, Du J*, Lü W*. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.
#Equal contributions
*Co-corresponding authors

Haley E, Choi W, Fan C, Sun W, Du J, Lü W. 2019. Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy. J Vis Exp (143):e58754, doi:10.3791/58754.

Fan C*, Choi W*, Sun W, Du J, Lü W. 2018. Structure of the human lipid-gated cation channel TRPC3. eLife:e36852.

Fan C*, Choi W*, Sun W, Du J, Lü W. 2018. Structure of the human lipid-gated cation channel TRPC3. eLife 4;7.
*Co-first author

Huang W, Choi W, Chen Y, Zhang Q, Deng H, He W, Shi Y. 2013. A proposed role for glutamine in cancer cell growth through acid resistance. Cell Res 23:724–727.

Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y. 2013. Mechanistics insights into CED-4-mediated activation of CED-3. Genes Dev 27:2039–2048.

Huang W, Choi W, Hu W, Mi N, Guo Q, Ma M, Liu M, Tian Y, Lu P, Wang FL, Deng H, Liu L, Gao N, Yu L, Shi Y. 2012. Crystal structure and biochemical analyses reveal Beclin1 as a novel membrane binding protein. Cell Res 22:473–389.